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Koti, B. C.
- Effect of Bauhinia variegate Bark Extract on Blood Glucose Level in Normal and Alloxanised Diabetic Rats
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Journal of Natural Remedies, Vol 9, No 1 (2009), Pagination: 27-34Abstract
The antidiabetic activity of Ethanol (95%) bark extract of Bauhinia variegata Linn. was evaluated in alloxaninduced diabetic rats. The various parameters like blood glucose, body weight, total cholesterol, triglycerides, high density lipoprotein, insulin, oral glucose tolerance test and histopathology of pancreas were studied. The results were found to be significant antidiabetic by reducing the blood glucose level, improving body weight, attenuating the altered lipid profile toward the normal and by regenerating the Islets of langerhans. Therefore the present study justifies that ethanol extract of Bauhinia variegata exhibits significant antidiabetic activity, so this extract may have Insulin-like properties.Keywords
Anti-diabetic Activity, Bauhinia variegata Linn, Islet of Langerhans, Plasma Biochemical ParametersFull Text
- Antihyperlipidemic and Antiperoxidative Effect of Dibola a Polyherbal Formulation in Alloxan Induced Diabetic Rats
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Authors
B. C. Koti
1,
R. A. Patil
2
Affiliations
1 Tatyasaheb Kore College of Pharmacy, Warananagar, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar. Tal-Panhala, Dist-Kolhapur. Pin-416113, IN
1 Tatyasaheb Kore College of Pharmacy, Warananagar, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar. Tal-Panhala, Dist-Kolhapur. Pin-416113, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 102-107Abstract
This study was undertaken to investigate the effect of Dibola, a polyherbal formulation composed of medicinal plants on blood glucose, plasma insulin, serum lipid profile and lipidperoxidation in alloxan induced diabetes rats. Dibola, was administered orally (242 mg/kg body weight) for 21 days. The effect of Dibola on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS and Hydroperoxides] and serum lipids [cholesterol, triglyceride, LDL, HDL and VLDL] were also estimated in alloxan induced diabetic rats. The effects were compared with standard drug Gilbenclamide. Treatment with Dibola and Gilbenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Dibola also resulted in a significant decrease in serum cholesterol, increase HDL and reduction in tissue lipid peroxide formation. The effect produced by Dibola was comparable with that of Gilbenclamide.The decreased lipid peroxides, serum cholesterol, increase HDL levels clearly showed the antihyperlipidemic and antiperoxidative effect of Dibola apart from its antidiabetic effect.
Keywords
Dibola, Alloxan, Antihyperlipidemic, Antiperoxidative.
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